Mazzeo is an Italian surname. Notable people with the surname include:
Fabio Mazzeo (born 1983), Italian footballer Edward Mazzeo (born 1980), American Sporting Arms Executive Rafe Mazzeo (born 1961), American mathematician Rosario Mazzeo (1911–1997), American clarinetist Vince Mazzeo (born 1964), American politician Tilar J. Mazzeo (born 1971), American writer Larry Mathews (born Mazzeo 1955), American child actor: The Dick Van Dyke Show
See also Mazzeo Island, an island of Antarctica