Estriol sulfate glucuronide, or estriol 3-sulfate 16α-glucuronide, is an endogenous, naturally occurring diconjugated metabolite of estriol. It is generated in the liver from estriol sulfate by UDP-glucuronyltransferase and is eventually excreted in the urine by the kidneys. It occurs in high concentrations during pregnancy along with estriol sulfate and estriol glucuronide, and was a component of the early pharmaceutical estrogens Progynon and Emmenin.
Formation In the human liver, a glucuronosyltransferase anzyme converts estriol sulfate to its glucuronide by adding a sugar acid at one of the hydroxy groups, with uridine diphosphate (UDP) as byproduct:
See also Catechol estrogen Estrogen conjugate Lipoidal estrogen
References
External links Metabocard for Estriol 3-sulfate 16α-glucuronide (HMDB10356) - Human Metabolome Database