Guajardo is a Spanish surname that may refer to:
Andrés Guajardo (1930–2000), Spanish jurist, businessman and politician Anisa Guajardo (born 1991), Mexican-American football striker Carlos Alberto Guajardo Romero (1973–2010), Mexican journalist Daniela Guajardo (born 1990), Chilean road cyclist Fabiola Guajardo (born 1987), Mexican actress and model Ildefonso Guajardo Villarreal (born 1957), Mexican economist and politician Juan Antonio Guajardo Anzaldúa (1958–2007), Mexican politician Jorge Guajardo, Mexican politician and diplomat Luis Guajardo (born 1973), Chilean football player Mary Telma Guajardo (born 1959), Mexican politician Rafael Aguilar Guajardo (1950–1993), Mexican drug lord and federal police commander René Guajardo (1933–1992), Mexican professional wrestler Roberto Guajardo Suárez (1918–2008), Mexican lawyer Víctor Guajardo (born 1990), Mexican football player