Migliaccio is an Italian surname. Notable people with the surname include:
Dirce Migliaccio (1933–2009), Brazilian actress Flávio Migliaccio (1934–2020), Brazilian actor, film director and screenwriter Giulio Migliaccio (born 1981), Italian footballer Lucia Migliaccio (1770–1826), wife of Ferdinand I of the Two Sicilies Oreste Migliaccio (1882–1973), American jazz pianist, composer and bandleader Sergio Migliaccio (born 1974), Uruguayan footballer Lance Migliaccio (born 1963), American actor, producer, videocast/podcast host, and political activist
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