A puffball is a type of fungi.
Puffball may also refer to:
The seeding flower head of a dandelion Puffball (novel), a 1980 supernatural novel by Fay Weldon Puffball (film), a 2007 British film adaptation of the novel Puffball, a character from the second season of Battle for Dream Island, an animated web series Puffball Collective, a Marvel Comics group Puffball Islands, a group of Antarctic islands
See also Caenocara, a beetle genus, some species of which are known as puffball beetles