Trealease is a surname. Notable people with the surname include:
Allen W. Trelease (c. 1928/1929–2011), American historian, author, and professor George E. Trelease, namesake of the George E. Trelease Memorial Baseball Park in Springfield, Massachusetts Jim Trelease (born 1941), American educator and author Richard M. Trelease, Jr. (1921–2005), bishop of the Episcopal Diocese of the Rio Grande William Trelease (1857–1945), American botanist, entomologist, and explorer