Gelperin is a surname. Notable people with the surname include:

Alan Gelperin, the scientist and biologist currently at Princeton University. Dave Gelperin chaired the working groups developing the IEEE 829-1989 software testing documentation standard. (1903–1989), the Soviet chemical engineer who designed the FAB-5000 bomb. See also Galperin, a list of people with the surname Halperin, a list of people with the surname Galperina, a list of people with the surname