Orlandini is an Italian surname. Notable people with the surname include:
Giulio Orlandini, Italian painter Giuseppe Orlandini (1922–20??), Italian film director and screenwriter Giuseppe Maria Orlandini (1676–1760), Italian Baroque composer Leovanna Orlandini (born 1978), Ecuadorian beauty pageant winner Lia Orlandini (1896–1979), Italian actress Niccolò Orlandini (1554–1606), Italian Jesuit writer Pierluigi Orlandini (born 1972), Italian footballer Raúl Orlandini (1952–2006), Peruvian racing driver Rodolfo Orlandini (1905–1990), Argentine footballer and manager Vincenzo Orlandini (1910–1961), Italian football referee