Wesche is a surname. Notable people with the name include:
Maddi Wesche (born 1999), New Zealand shot putter Phoebe Wesche (1871–1950) Australian charity worker and clubwoman Terje Wesche (born 1947), Norwegian sprint canoer Walter Wesché (1857–1910), British composer and entomologist Willy Wesche, German World War II oberst
See also Wesch