E2C may refer to:
E-2C Hawkeye, a version of Northrop Grumman E-2 Hawkeye Estradiol cypionate, an estrogen medication Pennsylvania Railroad class E2c, an experimental locomotive Emulsion to combustion, a process for making emulsified fuel E2C, a Euphoria (programming language)-to-C translator execution mode Endure to Cure Foundation, a non-profit foundation Employability and Employment Centre, a programme by Autism Resource Centre (Singapore)