Knob Creek is a stream in Iron and St. Francois counties in the U.S. state of Missouri. It is a tributary of Stouts Creek.

The stream headwaters arise on the west flank of Oak Mountain at an elevation of 1400 feet. The stream flows west-southwest to enter the adjacent valley near Lopez about one mile south of Middlebrook in the southwest corner of St. Francois County. The stream enters Iron County and turns south-southeast and flows past Pilot Knob and Ironton to its confluence with Stouts Creek.Graniteville, Missouri, Ironton, Missouri, and Lake Killarney, Missouri,7.5 Minute Topographic Quadrangles, USGS, 1968

The source area is at and the confluence is at .

Knob Creek was named for a summit along its course called Pilot Knob.

See also List of rivers of Missouri

References