The women's 100 metre butterfly S10 event at the 2016 Paralympic Games took place on 12 September 2016, at the Olympic Aquatics Stadium. Two heats were held. The swimmers with the eight fastest times advanced to the final.

Heats Heat 1 10:51 12 September 2016:

Rank Lane Name Nationality Time Notes 1 5 1:11.22 2 6 1:11.42 3 2 1:12.89 4 4 1:12.98 5 7 1:13.81

Heat 2 10:55 12 September 2016: Rank Lane Name Nationality Time Notes 1 4 1:04.37 2 5 1:08.62 3 3 1:09.39 4 6 1:11.12 5 2 1:13.40 6 7 1:14.50

Final 18:43 12 September 2016:

Rank Lane Name Nationality Time Notes 4 1:02.65 5 1:06.92 2 1:08.77 4 3 1:09.23 5 6 1:09.73 6 7 1:10.55 7 8 1:11.92 8 1 1:13.56

Notes