The women's 100 metre backstroke S12 event at the 2016 Paralympic Games took place on 14 September 2016, at the Olympic Aquatics Stadium. No heats were held.

Final 18:40 14 September 2016:

Rank Lane Name Nationality Time Notes 4 1:06.06 5 1:11.97 3 1:12.73 4 6 1:15.24 5 7 1:21.33 6 2 1:21.73 7 1 1:22.79 8 8 1:26.75

References