Karakatsanis is a Greek surname. Notable people with the surname include:
Karakatsanis (athlete), Greek shooter in the 1896 Olympics Andromache Karakatsanis (born 1955), justice on the Supreme Court of Canada Konstantinos Karakatsanis (born 1877, date of death unknown), Greek runner in the 1896 Olympics Thymios Karakatsanis (1940–2012), Greek actor