This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list; for esters, see here instead.
Estradiol derivatives Compound Chemical name Structure Marketed Estradiol (E2) Estra-1,3,5(10)-triene-3,17β-diol ✓ 2-Hydroxyestradiol 2-Hydroxyestradiol – 4-Hydroxyestradiol 4-Hydroxyestradiol – 4-Methoxyestradiol 4-Methoxyestradiol – 8β-VE2 8β-Vinylestradiol – 16α-IE2 16α-Iodoestradiol – 16α-LE2 Estradiol 21,16α-lactone? – Cloxestradiol Estradiol 17β-chloral hemiacetal ether – Cloxestradiol acetate Estradiol 17β-chloral hemiacetal ether O,O-diacetate ✓ Estradiol sulfate Estradiol 3-sulfate – Estrapronicate Estradiol 3-propionate 17β-nicotinate ✓ Orestrate Estradiol 3-propionate 17β-(1-cyclohexenyl) ether – Polyestradiol phosphate Estradiol 17β-phosphate polymer ✓ Promestriene Estradiol 3-propyl 17β-methyl diether ✓
17α-Substituted estradiol derivatives Compound Chemical name Structure Marketed Cyclodiol 14α,17α-Ethanoestradiol – Estrazinol 8-Aza-17α-ethynylestradiol 3-methyl ether – Estrofurate 17α-(3-Furyl)-δ7-estradiol 3-acetate – Etamestrol (eptamestrol) 1-Hydroxy-7α-methyl-17α-ethynylestradiol 1,3-dibenzoate – Ethinylestradiol (EE) 17α-Ethynylestradiol ✓ Ethinylestradiol sulfonate (EES) 17α-Ethynylestradiol 3-isopropylsulfonate ✓ Ethylestradiol 17α-Ethylestradiol – Mestranol (EE3ME) 17α-Ethynylestradiol 3-methyl ether ✓ Methylestradiol 17α-Methylestradiol ✓ Moxestrol 11β-Methoxy-17α-ethynylestradiol ✓ Quinestrol 17α-Ethynylestradiol 3-cyclopentyl ether ✓ RU-16117 11α-Methoxy-17α-ethynylestradiol –
Nitrogen mustard-coupled alkylating antineoplastic estradiol derivatives Compound Chemical name Structure Marketed Alestramustine Estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(2β-aminopropanoate) – Atrimustine Estradiol 3-benzoate 17β-(4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate – Estramustine Estradiol 3-(bis(2-chloroethyl)carbamate) – Estramustine phosphate Estradiol 3-(bis(2-chloroethyl)carbamate) 17β-phosphate ✓
17β-Aminoestrogens
Compound Chemical name Structure Marketed Aminoestradiol 17β-Aminoestradiol – Butolame 17β-((4-Hydroxybutyl)amino)estradiol – Hexolame 17β-((6-Hydroxyhexyl)amino)estradiol – Pentolame 17β-((5-Hydroxypentyl)amino)estradiol – Prodiame 17β-((3-Aminopropyl)amino)estradiol – Prolame 17β-((3-Hydroxypropyl)amino)estradiol –
Estrone derivatives Compound Chemical name Structure Marketed Estrone (E1) Estra-1,3,5(10)-triene-3-ol-17-one ✓ 2-Hydroxyestrone 2-Hydroxyestrone – 4-Hydroxyestrone 4-Hydroxyestrone – 4-Methoxyestrone 4-Methoxyestrone – 16α-Hydroxyestrone 16α-Hydroxyestrone – Almestrone 7α-Methylestrone ✓ Clomestrone 16α-Chloroestrone 3-methyl ether ✓ Estrone sulfate Estrone 3-sulfate ✓ Estropipate Estrone 3-sulfate piperazine salt ✓ Hydroxyestrone diacetate 16α-Hydroxyestrone 3,16α-diacetate ✓
Nitrogen mustard-coupled alkylating antineoplastic estrone derivatives Compound Chemical name Structure Marketed Estromustine Estrone 3-(bis(2-chloroethyl)carbamate) –
Estriol derivatives Compound Chemical name Structure Marketed Estriol (E3) 16α-Hydroxyestradiol ✓ Estetrol (E4) 15α-Hydroxyestriol – Quinestradol Estriol 3-cyclopentyl ether ✓
17α-Substituted estriol derivatives Compound Chemical name Structure Marketed Cyclotriol 14α,17α-Ethanoestriol – Ethinylestriol 17α-Ethynylestriol – Nilestriol 17α-Ethynylestriol 3-cyclopentyl ether ✓
Other estrogen derivatives
Epimers Compound Chemical name Structure Marketed 17α-Estradiol (alfatradiol) 17α-Estradiol ✓ 16β-Epiestriol (epiestriol) 16β-Hydroxy-17β-estradiol ✓ 17α-Epiestriol 16α-Hydroxy-17α-estradiol – 16β,17α-Epiestriol 16β-Hydroxy-17α-estradiol – Epimestrol 17α-Epiestriol 3-methyl ether ✓ Mytatrienediol 16α-Methyl-16β-epiestriol 3-methyl ether –
Equine estrogens
Compound Chemical name Structure Marketed Equilin Δ7-Estrone ✓ Equilenin Δ6,8-Estrone ✓ 17α-Dihydroequilin Δ7-17α-Estradiol ✓ 17β-Dihydroequilin Δ7-17β-Estradiol ✓ 17α-Dihydroequilenin Δ6,8-17α-Estradiol ✓ 17β-Dihydroequilenin Δ6,8-17β-Estradiol ✓ 8,9-Dehydroestrone Δ8-Estrone ✓ 8,9-Dehydroestradiol Δ8-17β-Estradiol ✓ Hippulin Δ8-14-Isoestrone ✓
See also List of steroids
Notes ? = Chemical names that are unverified.
References