The surname Mussafia, Musafia, or Musaphia, or Mussaphia may refer to:
Adolf Mussafia (1835–1905), Austrian philologist from Dalmatia Benjamin Musaphia (c. 1606 – 1675), Jewish doctor, scholar and kabbalist Ḥayyim Yitzḥak Mussafia (1760–1837), Talmudist Joseph Musaphia (born 1935), a New Zealand writer and actor Julien Musafia (1925–2015), American pianist and musicologist
See also Mussaf Mussafah