Hobo Branch is a stream in Crawford County in the U.S. state of Missouri. It is a tributary of Blue Springs Creek within the Blue Springs Creek Conservation Area.
The stream headwaters arise at and it flows to the northeast passing under Missouri Route N just south of its confluence with Blue Springs Creek at . The confluence is at an elevation of and located about four miles southeast of Bourbon.Missouri Atlas & Gazetteer, DeLorme, 1998, First edition, p. 47
Hobo Branch took its name from a nearby mine, the Hobo Sulphur and Iron Mines, where it was claimed hoboes worked.
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