Pessina is an Italian surname. Notable people with the surname include:
Giorgio Pessina (1902–1977), Italian fencer Giovanni Pessina (1836–1904), Italian painter Jean Pessina, Swiss slalom canoeist Massimo Pessina (born 2007), Italian footballer Matteo Pessina (born 1997), Italian footballer Stefano Pessina (born 1941), Italian-born Monegasque billionaire