Isa Khel (Pashto: عیسیٰ خیل) is a sub-tribe of the Pashtun Niazi tribe. The earliest recorded mention of the Isa Khel tribe is in Baburnama, 1504-1505. Most of the tribe still resides in their ancestral town of Isakhel, named after their ancestor Isa Khan Niazi son of Umar Khan Niazi, but a lot have shifted to bigger cities or different towns in pursuit of a better education and livelihood opportunities.
Clans Zakku Kheyl Many in the southern area of Isakhel belong to this clan, most influential due to their substantial agriculture land. Mammu Khel This tribe mainly live in southern suburbs and villages of Isakhel comprising 60% population of Isa Khel sub-tribe. The names of their villages are Khaglanwala, Behu, Sarwar Khel, Wandha Ghalay Khel, Attock Paniala, and Khira in Laki Marwat District. A notable sub-clan is Khizar Khel Appoo Khel People of this clan live in Isakhel city with unchanged name of Appo Khel Badunzye People of this clan live in the southern villages of Isa Khel city. Maulana Abdusattar Khan Niazi belonged to this particular clan.
Notable people Abdul Hafeez Khan, politician Abdul Razzaq Khan, politician Abdul Rehman Khan, politician Abdul Sattar Khan Niazi, religious and political leader Attaullah Khan Esakhelvi, folk musician Maqbool Ahmed Khan (MNA), politician Col. Mohammad Aslam Khan, politician Zakia Shahnawaz Khan, politician
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