Flight 121 may refer to the following accidents involving commercial airliners:
Listed chronologically Pan Am Flight 121, crashed on 18 June 1947 Mohawk Airlines Flight 121, crashed on 2 July 1963 Air Fiji Flight 121, crashed on 24 July 1999
Other uses Pacific Air Flight 121, working title of the 2006 movie Snakes on a Plane South Pacific Airlines Flight 121, a fictional flight in the 2006 movie Snakes on a Plane
See also
STS-121, a successful Space Shuttle mission in June–July 2006