Knob Creek is a stream in west central Bates County in the U.S. state of Missouri. It is a tributary of Miami Creek.
The stream headwaters arise about 1.5 miles southwest of the community of Burdett and the stream flows south crossing Missouri Route 18 one-half mile west of Lacyville. The stream continues to the south to south-southeast passing under Missouri Route F to its confluence with Miami Creek about three miles northeast of Virginia on Missouri Route 52 and seven miles west-northwest of Butler and US Route 71.Missouri Atlas & Gazetteer, DeLorme, 1998, First edition, p. 42,
The stream source area is at and the confluence is at .
The name Knob is a corruption of Knabb, the surname of a settler.
See also List of rivers of Missouri
References