Tefé may refer to:
Tefé, municipality in the state of Amazonas, Brazil Tefé River, river in the state of Amazonas, Brazil Tefé Airport, airport in Amazonas, Brazil Roman Catholic Territorial Prelature of Tefé, Catholic prelature in Brazil Tefé Holland, DC Comics fictional character Barão de Teffé (H-42), former Brazilian oceanographic research ship