William Byers (1831–1903) was a Nebraska politician.
William Byers may also refer to: William P. Byers (born 1943), Canadian mathematician and philosopher Billy Byers (1927–1996), American jazz trombonist and arranger
See also Will Byers, fictional character Bill Byers (1877–1948), baseball player Byers, Colorado, town named for William Byers George Byers (footballer), or George William Byers