The term end organ or end-organ has two meanings in medicine: A small organ at the terminal end of a nerve conduction pathway Bulbous corpuscle (Ruffini corpuscle end-organ) Tactile corpuscle (Meissner corpuscle end-organ) Merkel nerve ending (Merkel corpuscle end-organ) Neuromuscular junction (motor end-organ) Lamellar corpuscle (Pacinian corpuscle end-organ) The ultimately affected organ in a chain of events, such as a disease process (pathophysiology) or a drug's mechanism of action (sometimes called a target organ in this sense) End organ damage, disease of such organs Ambulatory blood pressure § Target organ damage Sepsis § End-organ dysfunction HFE hereditary haemochromatosis § End-organ damage