Balestrini is an Italian surname. Notable people with the surname include:
Alberto Balestrini (born 1931), Argentine fencer Alberto Balestrini (1947–2017), Argentine politician Carlo Balestrini (1868–1922), Italian painter Carlos Balestrini (1880–1972), Argentine sport shooter Giulio Balestrini (1907–?), Italian soccer player Nanni Balestrini (1935–2019), Italian poet