Piacentini is an Italian surname. Notable people with the surname include:
Genison Piacentini de Quadra (born 1988), Brazilian footballer Giorgio Piacentini (born 1997), Italian footballer Giovanni Piacentini (born 1968), Italian footballer John Piacentini, American psychologist Jorge Piacentini (1920–1995), Argentine sailor Luigi Piacentini (born 1930), Italian field hockey player Marcello Piacentini (1881–1960), Italian architect Matteo Piacentini (born 1999), Italian football player Pablo Piacentini (died 2017), Argentinian political scientist, journalist and activist Pio Piacentini (1846–1928), Italian architect Riccardo Piacentini (born 1958), Italian classical composer and pianist Rosy Piacentini (born 1938), French former swimmer Settimio Piacentini (1859–1921), Italian general Valentino Piacentini (born 1978), Italian former international table tennis player
Other Colli Piacentini ("Hills of Piacenza"), Italian wine region located at the western end of Emilia-Romagna