The 1915 Southwestern Pirates football team represented Southwestern University as a member of the Southwest Conference (SWC) during the 1915 college football season. Led first-year head coach J. Burton Rix, Southwestern compiled an overall record of 4–3 with a mark of 0–2 in SWC play.Spalding's Official Foot Ball Guide, p. 302, National Collegiate Athletic Association, 1915.

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