Humayun Khan may refer to:
Khan as surname Ala ud-din Sikandar Shah (died 1394), born Hamayun Khan, Sultan of Delhi Humayun Khan (diplomat) (1932–2022), Pakistani diplomat Humayun Saifullah Khan (born 1943), Pakistani politician Humayun Akhtar Khan (born 1955), Pakistani politician Humayun Khan (soldier) (1976–2004), Pakistani-American US Army soldier killed in action Humayun Khan (politician), Pakistani politician Humayun Muhammad Khan, Pakistani politician Munawar Humayun Khan (born 1941), Pakistani chair of the Board of Directors of the Sarhad Rural Support Programme
Khan as middle name Humayun Khan Bangash, Commander of the IV Corps of the Pakistan Army, 1993–1996 Humayun Khan Mandokhel (born 1962), Pakistani senator Mir Humayun Khan Marri (fl. 1997–2011), Pakistani senator Humayun Khan Panni, Deputy Speaker of the Jatiyo Sangsad of Bangladesh, 1991–1996