José Guzmán (born 1963) is a Puerto Rican baseball player.
José Guzmán may also refer to:
José Guzmán (footballer) (1891–1930), Spanish footballer José Guzmán (basketball) (1937–2026), Peruvian Olympic basketball player José Guzmán (boxer) (born 1963), Venezuelan boxer José Guzmán Santos (born 1947), Mexican politician José Florencio Guzmán (1929–2017), Chilean politician José de Guzmán Benítez (1857–1921), Mayor of Ponce, Puerto Rico José de Guzmán, 1st Viscount of San Rafael de la Angostura (1740–1792), Dominican cattle rancher, colonizer and nobleman
See also Juan José Guzmán (1800–1847), President of El Salvador (1842–1844) José Rocchi Guzmán (born 1988), Mexican football goalkeeper