Cruciani is an Italian surname. Notable people with the surname include:
Andrés Cruciani (born 1966), Argentine footballer and manager Enrico Cruciani Alibrandi (1839–1921), Italian politician Giuseppe Cruciani (born 1966), Italian radio presenter, television presenter and journalist Michele Cruciani (born 1986), Italian footballer Paola Tiziana Cruciani (born 1958), Italian actress, comedian and playwright