Frank Clayton may refer to:
People Frank Clayton (Otago cricketer) (1866–1944), New Zealand cricketer Frank Clayton (Canterbury cricketer) (1866–1941), New Zealand cricketer Frank Clayton (American football) in 1955 NFL draft
Fictional characters Frank Clayton (Emmerdale), fictional character from the British soap opera Emmerdale Frank Clayton, character in Saratoga (film) Frank Clayton, character in Pleasures of the Rich
See also Francis Clayton (disambiguation)