Mazzotta is an Italian surname. Notable people with the surname include:
Anna Mazzotta (born 1970), British artist Antonio Mazzotta (born 1989), Italian footballer Federico Mazzotta (1839–1897), Italian painter Giuseppe Mazzotta, American historian Peppino Mazzotta (born 1971), Italian actor Riccarda Mazzotta (born 1986), Swiss cyclist Roberto Mazzotta (born 1940), Italian economist and politician