Franchini is an Italian surname. Notable people with the surname include:
Gene E. Franchini (1935–2009), American lawyer and judge Gianfranco Franchini (1938–2009), Italian architect Irene Franchini (born 1981), Italian archer Luca Franchini (born 1983), Italian footballer Niccolò Franchini (1704–1783), Italian painter Teresa Franchini (1877–1972), Italian actress