Del Buono is an Italian surname that may refer to Candido Del Buono (1618–1676), Italian maker of scientific instruments Federica Del Buono (born 1994), Italian middle-distance runner Gianni Del Buono (born 1943), Italian middle-distance runner, father of Federica Paolo Del Buono (1625–1659), Italian maker of scientific instruments, brother of Candido Marco del Buono (1402–1489), painter and woodworker

See also Buono (surname)