McLain is a surname. Notable people with the surname include:

Carrie M. McLain (1895–1973), American writer, teacher Denny McLain (born 1944), American baseball player Ellen McLain (born 1952), American voice actor Frank A. McLain (1852–1920), American politician Hardy McLain (born 1952), American hedge fund manager Jeremiah McLain Rusk (1830–1893), American politician, 15th governor of the state of Wisconsin Masey McLain (born 1994), American actress Matt McLain (born 1999), American baseball player Mitch McLain (born 1993), American hockey player Raymond S. McLain (1890–1954), American military general Tommy McLain (1940–2025), American singer

Fictional characters: Ember McLain, character from the animated series Danny Phantom

Other possible meanings McLain, Mississippi, United States McLain State Park, Michigan Big Jim McLain, a 1952 film starring John Wayne. Clan MacLaine of Lochbuie, a highland Scottish clan.

See also McLean (disambiguation) McLaine