Zardini is an Italian surname. Notable people with the surname include:
Elsa Matilde Zardini (1949–2020), Paraguayan/Argentinian botanist Edoardo Zardini (alpine skier) (born 1976), an Italian alpine skier Edoardo Zardini (cyclist) (born 1989), an Italian cyclist Ernesto Zardini (1908-1934), Italian ski jumper Mirko Zardini (born 1955), Italian curator Sergio Zardini (1931–1966), Italian bobsledder