Zacchia is an Italian surname. Notable people with the surname include:
Paolo Zacchia the Elder (1490–1561), Italian Renaissance painter Laudivio Zacchia (1565–1637), Italian cardinal Nicolle Zacchia (born 2010), Brazilian rhythmic gymnast Paul Zacchias or Paolo Zacchia (1584–1659), Italian physician, teacher of medical science and forensic medicine, medico-legal jurist, philosopher, poet Steve Zacchia (born 1982), Swiss racing driver