Archain 1 is a protein that in humans is encoded by the ARCN1 gene. Also called coatomer subunit delta, this protein is a component of the coatomer complex, and is involved in the (retrograde) transport of proteins from the Golgi apparatus to the endoplasmic reticulum.
Function
This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or vesicle trafficking.
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Further reading