Puccinelli is an Italian surname. Notable people with the surname include:
Aldo Puccinelli (1920–1994), Italian footballer André Puccinelli (born 1948), Brazilian politician Angelo Puccinelli, Italian painter Dorothy Wagner Puccinelli (1901–1974), American artist George Puccinelli (1907–1956), American baseball player Keith Puccinelli (1950–2017), American artist Luca Puccinelli (born 1973), Italian footballer Placido Puccinelli (1609–1685), Italian Christian monk and historian