Pybus is a surname. Notable people with this name include:
Cassandra Pybus (born 1947), Australian historian and author Charles Small Pybus (1766–1810), English barrister and politician Dan Pybus (born 1997), English footballer Dave Pybus (born 1970), English musician Frederick Charles Pybus (1883–1975), English surgeon George Pybus (1911–2001), English footballer John Pybus (1880–1935), British politician Oliver Pybus (born 1974), British biologist Richard Pybus (born 1964), English-born cricket coach Sean A. Pybus (born 1957), American Navy officer W. R. Pybus (1848–1917), South Australian organist