David Syme (1827–1908) was a Scottish-Australian newspaper proprietor (The Age).
David Syme may also refer to:
David Syme (footballer) (born 1997), Scottish footballer for Cowdenbeath, formerly of Kilmarnock and Partick Thistle David Syme (pianist) (born 1949), American pianist David Syme (referee) (1944–2020), Scottish football referee