Seydoux () is a French-language surname. Notable people with the surname include:
Camille Seydoux (born 1982), French stylist Balthazar Seydoux (born 1971), Monegasque politician François Seydoux de Clausonne (1905–1981), French diplomat Jacques Seydoux (1870–1929), French diplomat and economist Léa Seydoux (born 1985), French actress Léo Seydoux (born 1998), Swiss footballer Michel Seydoux (born 1947), French businessman and film producer Philippe Seydoux (born 1985), Swiss ice hockey player Roger Seydoux (1908–1985), French academic and diplomat