Michael O'Keefe (born 1955) is an American film and television actor.
Michael O'Keefe or O'Keeffe may also refer to:
Michael A. O'Keefe (born 1942), Australian physicist Michael Kenny O'Keefe (born 1963), American judge on the D.C. Superior Court Michael O'Keeffe (footballer) (born 1990), New Zealand footballer Michael O'Keeffe (chemist) (born 1934), American crystallographer Michael O'Keefe (Tasmanian politician) (1864–1926), Australian politician in Tasmania Michael O'Keefe (American politician) (1932–2021), American politician in Louisiana Michael O'Keeffe (Queensland politician) (1854–1941), Australian politician in Queensland Michael O'Keeffe, co-founder and first president of First National Stores
See also Miles O'Keeffe (born 1954), American movie star of the 1980s Michael Edwin Keefe (1844–1933), Nova Scotia politician Michael Keith (disambiguation)