Padovano is an Italian surname meaning "Paduan", "of Padua" or "from Padua". Notable people with the surname include:
Annibale Padovano (1527–1575), Italian composer and organist Antonello Padovano, Italian film director and producer Domenico Padovano (1940–2019), Italian Roman Catholic bishop Melinda Padovano (born 1987), American professional wrestler Michele Padovano (born 1966), Italian footballer