Devil's Backbone may refer to:
Places Devil's Backbone (rock formation), a rock formation near Charlestown, Indiana Devils Backbone (Highland County, Virginia), a small mountain in Highland County, Virginia Devil's Backbone State Forest, a state forest located in Shenandoah County, Virginia Devils Backbone Wilderness, a protected wilderness area in Ozark County, Missouri A ridge in the Ouachita Mountains, in Arkansas A ridge near Mount San Antonio in the San Gabriel Mountains, in California A region in Texas Hill Country
Plants Euphorbia tithymaloides, the so-called "Redbird cactus" which is actually a spurge Kalanchoe daigremontiana, a bryophyllum Cissus quadrangularis, a perennial plant of the grape family
Other uses The Devil's Backbone (El espinazo del diablo), a 2001 Spanish film
See also Battle of Devil's Backbone, a battle in the American Civil War Devils Backbone Brewing Company, a brewpub located in Roseland, Virginia Spina bifida, a birth defect