D'Amelio is an Italian surname, and may refer to:
Via D'Amelio bombing, a 1992 bombing in Sicily
People with the surname Anthony D'Amelio (born 1964), American politician Charli D'Amelio (born 2004), American social media personality Dixie D'Amelio (born 2001), American singer and social media personality Frank D'Amelio (born 1957), American soccer player
See also Amelio, a given name and surname D'Alelio, a surname