Děčín main station () is a railway station in the city of Děčín, in the Ústí nad Labem Region of the Czech Republic. The station originally opened in 1850 and the current building was constructed in 1865. It is located on the Děčín–Benešov nad Ploučnicí–Rumburk railway, Praha–Ústí nad Labem–Děčín railway, Děčín–Dresden-Neustadt railway and Děčín–Oldřichov u Duchcova railway. The train services are operated by Czech Railways () and other carriers.

From 2001 to 2003, the station was renovated along with the adjacent rail yard.

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