Serena Williams defeated Madison Keys in the final, 7–6(7–5), 6–3 to win the women's singles tennis title at the 2016 Italian Open. This was Williams's second title in Rome won without dropping a set, and her fourth Italian Open title overall.
Maria Sharapova was the reigning champion, but could not defend her title because of her provisional suspension after failing a drug test at the Australian Open.
Seeds The top eight seeds received a bye into the second round.
Draw
Finals
Top half Section 1
Section 2
Bottom half Section 3
Section 4
Qualifying Seeds
Qualifiers
Draw First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
Eighth qualifier
References
External links Main draw Qualifying draw