Signe or Signy is a feminine given name. It may also refer to:
René-Pierre Signé (born 1930), French politician "Le Signe" ("The Signal"), a short story by Guy de Maupassant "Signe", an Eric Clapton instrumental piece on the album Unplugged Signy Island, South Orkney Islands, Antarctica Signy Research Station, Signy Island 459 Signe, an asteroid