Valeriy Grigoryevich Makrushin (; 14 January 1940, Saidabad, Uzbek SSR, Soviet Union (now in Uzbekistan) 2003Макрушин, Валерий Григорьевич) was a cosmonaut for the Soviet Union.

Soviet space program Makrushin joined the Chelomey Design Bureau after graduating from the Leningrad Institute of Aviation Instrumentation in 1963. He was recruited to a cosmonaut team on March 22, 1972, and was one of the first cosmonauts selected from this design bureau. He became the head of the Chelomey OKB-52 Mashinostroyeniya cosmonaut team until it was disbanded on April 8, 1987. Makrushin then worked on the Almaz military program with the design bureau until his retirement.

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